This course offers an examination of the interaction between the principles of systems engineering and the design for specialty engineering areas. The focus of their interactions is viewed across the system life cycle. Special emphasis is given to contributions of the specialties to the essential knowledge development needed for concept exploration, requirements analysis and development, trade-offs and decisions with uncertainty, preliminary design, system integration, verification, and system validation. The students will use the international space station and its support systems for practical application of the principles introduced in this course. This is the second of two courses in systems engineering. Class Notes: Pre-requisite: ME53501.