What is indigeneity? How can we better understand the suffering, survival and resilience behind indigenous peoples’ struggles to be heard? Native communities are processing various kinds of globalization and legacies of colonization with different degrees of self-determination, territorially-based sovereignty and resistance. They may have aspirations for ethnonational state-building, but they lack their own “nation-state” and their lands are often disputed, sometimes under siege. While they are frequently lumped together as the “fourth world,” their social, economic, political and cultural revitalization conditions vary widely in “glocal” contexts that reveal activism at various levels of local, regional, state and global interactions. We debate U.N. concepts of indigeneity, federal or state recognition variations, and the salience of self-identity for individuals and First Nations communities. Particular attention is paid to American Indian communities, with international comparisons. The course is designed to enhance student understanding of multi-disciplinary, practical, ethical and human rights synergies that come together under the rubric of indigenous studies. The course builds on and is interactive with our indigenous studies website: https://indigeneity.georgetown.edu. An important focus is on student direct experience with indigenous organizations, in partnerships for mutual benefit and learning. Hot issues where student participation may be welcome include ecology protest; health services; legal groundwork for sacred lands claims, Native American Graves Protection and Repatriation Act [NAGPRA] logistics, language revitalization and prison justice.